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The finding that the increase in GLP-1 was only evident after intraduodenal glucose infusion and was minimal when metformin was administered immediately before intraduodenal glucose suggests that the effect of metformin on GLP-1 is primarily related to modulation of the glucosegut interaction [8, 34]

However, it is not possible to confirm it is the strongest weight loss medicine until more research and comparisons with approved treatments are available

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